Here are a few tidbits revealed during Square's conference:
Wolfenstein: Youngblood introduces the next Blazkowicz generation to the fight against the Nazis. Play as one of BJ’s twin daughters, Jess and Soph, as you search for your missing father in Nazi-occupied Paris.
And here are the details from the show:
No other information was given, but Bethesda confirmed that it is a single-player epic, and referred to it as a next-gen game. I'm not sure if they meant it would be a PS5 game, or if they just meant it is very ambitious, but I'll update if they clarify.